Our Mission
The primary goal of our research is to discover and understand the cellular, molecular and epigenetic mechanisms of gynecological diseases and reproductive functions influenced by environmental toxicants and recreational drugs, as well as to develop novel therapeutic strategies that are more effective than those currently employed by the medical community.
Endometriosis:
We are currently investigating immune dysfunction in the disease initiation, establishment and progression, as well as developing new innovative therapies to improve health outcomes of patients with endometriosis through inhibition of inflammatory mechanisms.
Reproductive Toxicology:
We focus on the transgenerational effects of environmental toxicants, especially bisphenol S, on male and female reproductive functions.
Cannabis:
We have expanded new research focusing on the transgenerational effects of cannabis on male and female reproductive functions.
Ovarian Cancer:
We have built on our finding that WNT/β-catenin signaling is a key mechanism of ovarian cancer development that can be targeted by niclosamide treatment. Our current projects are to examine the inhibitory mechanisms of niclosamide in chemoresistant ovarian cancer.
Endometrial Cancer:
We have generated the mouse model that mimics human type II endometrial cancer. Our current projects are to test the suitability of our model for testing novel treatment strategies, as well as discovering new molecular targets for which diagnostic and therapeutic strategies could be developed.